Katherine Heigl was cast in what would become her most high-profile role, as intern Dr. Isobel "Izzie" Stevens on Grey's Anatomy, an ABC medical drama. The show, originally introduced as a midseason replacement, has become a huge ratings success. The same year, Heigl landed the starring role of Karly Hert in the independent film Side Effects, about marketing and the pharmaceutical industry. In late 2006, Heigl was nominated for a Golden Globe award in the category, Best Supporting Actress in a Series, Mini-series, or Motion Picture Made for Television for her work on Grey's Anatomy